Vitreous Health:
Metabolic Needs, Structural Integrity & Supportive Nutrition
VITREOUS BODY: COMPOSITION
- Water (98-99%)
- Collagen fibers
- Glycosaminoglycans (GAGs), mainly hyaluronan
- Non-collagenous proteins
- Trace metals and elements
vitreous body: Functions1
Contributes to:
maintenance of intraocular media clarity
Anti-inflammatory support
maintenance of intraocular pressure
Represents a reservoir for nutrients and metabolites received from both the non-pigmented ciliary and retinal pigment epithelia.
Hyalocytes are the tissue-resident macrophages of the vitreous body and are considered to play pivotal roles in health and diseases of the vitreous.
They play a role in modulating intraocular inflammation in non-inflamed eyes, there by contributing to intraocular transparency.
VITREOUS DEGENERATION
Myodesopsia (vitreous floaters) refers to the perception of moving spots, threads, or cloud-like shapes in the visual field caused by opacities within the vitreous humor that cast shadows on the retina. These opacities typically arise from aggregation of collagen fibers or other particulate matter within the vitreous gel and are most commonly associated with age-related vitreous changes or posterior vitreous detachment2.
VITREOUS DEGENERATION1,2
RISK FACTORS
RISK FACTORS FOR VITREOUS BODY DEGENERATION1,2
DEHYDRATION
SURGERY
AGING
MYOPIA
RISK FACTORS FOR VITREOUS BODY DEGENERATION1,2
DEHYDRATION
SURGERY
AGING
MYOPIA
Endogenous and exogenous stressors lead to the excessive production of reactive oxigen species (ROS)1
Increased intravitreal oxidative stress biomarkers correlate with proteolytic enzymes and vitreous degeneration1
Increased exposure of the natural crystalline lens to oxygen and ROS promotes the progression of nuclear cataracts1
KEY FACTORS IN OCULAR HEALTH3,4
HYDRATION
DIET
targeted
supplementation
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Evidence-based solutions designed to support clinical excellence
References:
1. Ankamah et al. “Vitreous Anti oxidants, Degeneration, and Vitreo-Retinopathy:Exploring the Links”. 2020. Anti oxidants: 9, 7
2. Sebag et al Vitreous and Vision Degrading Myodesopsia. Progress in Retinal and Eye Research 2020
3. Sherwin et al Hydration, fluid regulation and the eye: in health and disease. Clinical and Experimental Ophthalmology 2015; 43: 749764
4. Lawrenson et al. Nutrition and Eye Health. Nutrients 2019, 11, 2123